Epigenetic Reprogramming: Resetting the Biological Clock
The groundbreaking discovery that cellular aging can be reversed through epigenetic reprogramming has opened unprecedented possibilities for longevity science. By transiently expressing Yamanaka factors like OCT4, SOX2, KLF4, c-MYC, researchers can reset DNA methylation patterns to more youthful configurations without erasing cellular identity. The Salk Institute’s 2020 study demonstrated that intermittent OSKM expression extends lifespan…